There are several ways to do that in DS. Most obvious options are with table_comparison transform (http://scn.sap.com/community/data-services/blog/2013/05/08/how-to-use-tablecomparison-transform and http://scn.sap.com/docs/DOC-51695) or using the Auto correct load option (http://scn.sap.com/docs/DOC-46567)in your target table.
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